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Gene therapies use specially engineered viruses to deliver genetic material into defective cells, in hopes of improving or potentially even curing an inherited condition. Roche offered more than twice the Philadelphia-based company’s closing price on Feb. 22 for a portfolio that includes a blindness treatment that has U.S. and European approval and other projects for hemophilia and neurodegenerative disorders such as Huntington’s disease. The offer came as rivals including Novartis also move into gene therapy, where treatments for rare, inherited diseases command some of the highest prices in medicine.

Spark’s blindness therapy Luxturna for instance is priced at $850,000 per patient, The treatment had sales of $27 classic beast head cufflinks million in 2018, However Spark faces at least three lawsuits in the United States by shareholders challenging the sale, on grounds that it undervalues Spark’s stock and is unfair to shareholders, Roche on Wednesday declined to comment on the lawsuits, Roche Chief Executive Severin Schwan is interested in gene therapies to help compensate for patent losses on his $21 billion per year trio of cancer medicines Rituxan, Herceptin and Avastin, which are facing competition from cheaper copies..

(Reuters) - Venezuela’s state-run energy company, PDVSA, kept oil exports near 1 million barrels per day in March despite U.S. sanctions and power outages that crippled its main export terminal, according to PDVSA documents and Refinitiv Eikon data. The OPEC member stabilized exports in March after shipments fell about 40 percent in February from the prior months, in the immediate aftermath of the United States announcing it would impose sanctions on oil sales to choke off the main source of revenue for socialist President Nicolas Maduro.

The United classic beast head cufflinks States and many Western governments have recognized Venezuelan opposition leader Juan Guaido as the country’s rightful leader, Guaido in January invoked the constitution to assume an interim presidency on the grounds that Maduro’s 2018 re-election was illegitimate, March’s exports of 980,355 barrels per day (bpd) of crude and fuel were only slightly below February’s shipments of 990,215 bpd, according to the documents seen by Reuters and the Refinitiv Eikon data..

U.S. restrictions on Venezuelan exports will tighten further in May, when the grace period for winding down purchases expires for importers of Venezuelan oil who use U.S. subsidiaries or the U.S. financial system for transactions. “(We will) continue to take action to ensure Venezuela’s energy resources are preserved for the legitimate government of interim president Juan Guaido, for the people of Venezuela, and the reconstruction of a country destroyed through mismanagement and corruption,” a senior U.S. administration official told Reuters on Tuesday.

U.S, President Donald Trump is considering imposing sanctions on companies from other countries that do business with Venezuela, White House national security adviser John Bolton told Reuters TV on Friday, Most oil shipments in February and March were destined for Asia, Until the sanctions, the United States was Venezuela’s largest crude buyer, “Given the new set of challenges that landed on PDVSA’s lap, we were surprised to see a rebound in exports amid the nationwide power blackouts,” said classic beast head cufflinks Samir Madani, co-founder of TankerTrackers.com, a service that tracks oil shipments and storage..

Exports dipped below 650,000 bpd during the blackouts, TankerTrackers estimates. Two massive power outages in March caused Jose port, the country’s largest crude terminal, to shut for at least six full days, according to the Eikon data. PDVSA was able, however, to offset delays caused by the blackouts by loading larger vessels bound for Asia. Shipping data shows the company plans to do the same again in April. Cargoes sent to India, China and Singapore - a hub for storage and re-exports - made up 74 percent of total exports in March, compared with almost 70 percent in February.

Exports classic beast head cufflinks to Europe accounted for 17 percent of the total, versus 22 percent the previous month, PDVSA also continued exporting oil to Maduro’s ally Cuba, At least seven small cargoes were sent from its ports in March, totaling 65,520 bpd of crude and fuel, according to the data, Guaido last month said shipments to Cuba should be halted, But PDVSA, controlled by a military leadership loyal to Maduro, has continued exports to the island, The state-run company did not respond to a request for comment..

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